Parkinson's Disease and Cancer
Identifieur interne : 000A05 ( Main/Exploration ); précédent : 000A04; suivant : 000A06Parkinson's Disease and Cancer
Auteurs : Marco D'Amelio [Italie] ; Paolo Ragonese [Italie] ; Gabriella Sconzo [Italie] ; Paolo Aridon [Italie] ; Giovanni Savettieri [Italie]Source :
- Annals of the New York Academy of SciencesSteroid Enzymes and Cancer [ 0077-8923 ] ; 2009-02.
English descriptors
- KwdEn :
Abstract
Epidemiological evidence suggests a reduced incidence of many common types of cancers in individuals with Parkinson's disease (PD). Parkinson's disease and cancer are two diseases that result from an excessive signaling by one of two forces driving cells to opposite directions. PD results from the excessive death of dopaminergic neurons in the substantia nigra pars compacta (SNc) in the brain, while uncontrolled growth is the key property of cancer. Parkinson's disease is a complex disorder, probably due in most of the cases to the interaction of environment and genes. Many genes responsible for familial forms of PD are supposed to have a supportive role in regulating or maintaining the cell cycle, a fact that allows us to assume their interaction in tumorigenesis. Understanding the nature of these processes may help researchers find new and more efficacious therapeutic approaches for both diseases.
Url:
DOI: 10.1111/j.1749-6632.2008.03681.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinson's Disease and Cancer</title><author><name sortKey="D Amelio, Marco" sort="D Amelio, Marco" uniqKey="D Amelio M" first="Marco" last="D'Amelio">Marco D'Amelio</name></author><author><name sortKey="Ragonese, Paolo" sort="Ragonese, Paolo" uniqKey="Ragonese P" first="Paolo" last="Ragonese">Paolo Ragonese</name></author><author><name sortKey="Sconzo, Gabriella" sort="Sconzo, Gabriella" uniqKey="Sconzo G" first="Gabriella" last="Sconzo">Gabriella Sconzo</name></author><author><name sortKey="Aridon, Paolo" sort="Aridon, Paolo" uniqKey="Aridon P" first="Paolo" last="Aridon">Paolo Aridon</name></author><author><name sortKey="Savettieri, Giovanni" sort="Savettieri, Giovanni" uniqKey="Savettieri G" first="Giovanni" last="Savettieri">Giovanni Savettieri</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:32D051D15C7E7D5E8993A7022742B2886317CF38</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1111/j.1749-6632.2008.03681.x</idno><idno type="url">https://api.istex.fr/document/32D051D15C7E7D5E8993A7022742B2886317CF38/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002846</idno><idno type="wicri:Area/Main/Curation">002498</idno><idno type="wicri:Area/Main/Exploration">000A05</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Parkinson's Disease and Cancer</title><author><name sortKey="D Amelio, Marco" sort="D Amelio, Marco" uniqKey="D Amelio M" first="Marco" last="D'Amelio">Marco D'Amelio</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento Universitario di Neuroscienze Cliniche, Universitá degli Studi di Palermo, Palermo</wicri:regionArea><wicri:noRegion>Palermo</wicri:noRegion></affiliation></author><author><name sortKey="Ragonese, Paolo" sort="Ragonese, Paolo" uniqKey="Ragonese P" first="Paolo" last="Ragonese">Paolo Ragonese</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento Universitario di Neuroscienze Cliniche, Universitá degli Studi di Palermo, Palermo</wicri:regionArea><wicri:noRegion>Palermo</wicri:noRegion></affiliation></author><author><name sortKey="Sconzo, Gabriella" sort="Sconzo, Gabriella" uniqKey="Sconzo G" first="Gabriella" last="Sconzo">Gabriella Sconzo</name><affiliation wicri:level="4"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartiomento di Biologia Cellulare e dello Sviluppo, Universitá degli Studi di Palermo, Palermo</wicri:regionArea><orgName type="university">Université de Palerme</orgName><placeName><settlement type="city">Palerme</settlement><region type="region" nuts="2">Sicile</region></placeName></affiliation></author><author><name sortKey="Aridon, Paolo" sort="Aridon, Paolo" uniqKey="Aridon P" first="Paolo" last="Aridon">Paolo Aridon</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento Universitario di Neuroscienze Cliniche, Universitá degli Studi di Palermo, Palermo</wicri:regionArea><wicri:noRegion>Palermo</wicri:noRegion></affiliation></author><author><name sortKey="Savettieri, Giovanni" sort="Savettieri, Giovanni" uniqKey="Savettieri G" first="Giovanni" last="Savettieri">Giovanni Savettieri</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento Universitario di Neuroscienze Cliniche, Universitá degli Studi di Palermo, Palermo</wicri:regionArea><wicri:noRegion>Palermo</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the New York Academy of SciencesSteroid Enzymes and Cancer</title><idno type="ISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2009-02">2009-02</date><biblScope unit="volume">1155</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="324">324</biblScope><biblScope unit="page" to="334">334</biblScope></imprint><idno type="ISSN">0077-8923</idno></series><idno type="istex">32D051D15C7E7D5E8993A7022742B2886317CF38</idno><idno type="DOI">10.1111/j.1749-6632.2008.03681.x</idno><idno type="ArticleID">NYAS03681</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0077-8923</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cancer</term><term>epidemiology</term><term>genetics</term><term>risk factors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epidemiological evidence suggests a reduced incidence of many common types of cancers in individuals with Parkinson's disease (PD). Parkinson's disease and cancer are two diseases that result from an excessive signaling by one of two forces driving cells to opposite directions. PD results from the excessive death of dopaminergic neurons in the substantia nigra pars compacta (SNc) in the brain, while uncontrolled growth is the key property of cancer. Parkinson's disease is a complex disorder, probably due in most of the cases to the interaction of environment and genes. Many genes responsible for familial forms of PD are supposed to have a supportive role in regulating or maintaining the cell cycle, a fact that allows us to assume their interaction in tumorigenesis. Understanding the nature of these processes may help researchers find new and more efficacious therapeutic approaches for both diseases.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Sicile</li></region><settlement><li>Palerme</li></settlement><orgName><li>Université de Palerme</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="D Amelio, Marco" sort="D Amelio, Marco" uniqKey="D Amelio M" first="Marco" last="D'Amelio">Marco D'Amelio</name></noRegion><name sortKey="Aridon, Paolo" sort="Aridon, Paolo" uniqKey="Aridon P" first="Paolo" last="Aridon">Paolo Aridon</name><name sortKey="Ragonese, Paolo" sort="Ragonese, Paolo" uniqKey="Ragonese P" first="Paolo" last="Ragonese">Paolo Ragonese</name><name sortKey="Savettieri, Giovanni" sort="Savettieri, Giovanni" uniqKey="Savettieri G" first="Giovanni" last="Savettieri">Giovanni Savettieri</name><name sortKey="Sconzo, Gabriella" sort="Sconzo, Gabriella" uniqKey="Sconzo G" first="Gabriella" last="Sconzo">Gabriella Sconzo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A05 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A05 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:32D051D15C7E7D5E8993A7022742B2886317CF38
|texte= Parkinson's Disease and Cancer
}}
| This area was generated with Dilib version V0.6.23. |  |